网站地图 联系我们搜索内部网English | 中国科学院
首页 所况简介 机构设置 科研队伍 科学研究平台 院地合作 党群园地 国际交流 博士后 研究生教育 信息公开
科研进展
成果报道
最新重要论文(影响因子PNAS及以上)
发表论文数据库
所级学术报告
科学成果
发表论文
专著
专利
获奖
专题
所史丛书
所庆专辑
建所50周年画册
现在位置:首页 > 科研进展 > 最新重要论文(影响因子PNAS及以上)
The ER-Localized Transmembrane Protein TMEM39A/SUSR2 Regulates Autophagy by Controlling the Trafficking of the PtdIns(4)P Phosphatase SAC1, Molecular Cell, 2 Dec 2019
2019-11-28 | 【     】【打印】【关闭

Molecular Cell2 December, 2019,DOI:https://doi.org/10.1016/j.molcel.2019.10.035

The ER-Localized Transmembrane Protein TMEM39A/SUSR2 Regulates Autophagy by Controlling the Trafficking of the PtdIns(4)P Phosphatase SAC1

Guangyan Miao, Yujie Zhang, Di Chen, Hong Zhang

Summary

TMEM39A, encoding an ER-localized transmembrane protein, is a susceptibility locus for multiple autoimmune diseases. The molecular function of TMEM39A remains completely unknown. Here we demonstrated that TMEM39A, also called SUSR2, modulates autophagy activity by regulating the spatial distribution and levels of PtdIns(4)P. Depletion of SUSR2 elevates late endosomal/lysosomal PtdIns(4)P levels, facilitating recruitment of the HOPS complex to promote assembly of the SNARE complex for autophagosome maturation. SUSR2 knockdown also increases the degradative capability of lysosomes. Mechanistically, SUSR2 interacts with the ER-localized PtdIns(4)P phosphatase SAC1 and also the COPII SEC23/SEC24 subunits to promote the ER-to-Golgi transport of SAC1. Retention of SAC1 on the ER in SUSR2 knockdown cells increases the level of PtdIns(3)P produced by the VPS34 complex, promoting autophagosome formation. Our study reveals that TMEM39A/SUSR2 acts as an adaptor protein for efficient export of SAC1 from the ER and provides insights into the pathogenesis of diseases associated with TMEM39A mutations.

文章链接:https://www.sciencedirect.com/science/article/pii/S1097276519308135?via%3Dihub

相关报道:http://yhyhdlzzc565.117pt.com/kyjz/zxdt/201911/t20191129_5445022.html

 

 

 

评 论
          
版权所有:中国科学院生物物理研究所     京ICP备05002792号 京公网安备 110402500011 号
地址:北京市朝阳区大屯路15号(100101) 电话:010-64889872
意见反馈联系人:侯文茹 电子邮件:houwenru@ibp.ac.cn
网站地图 bet36代理最占成 优发优惠代理最占成 澳门银河优惠代理最占成
申博导航 沙龙365官网登入 188申博直属现金网 sunbet 申博138
澳门网上正规赌场 私彩平台 百合彩票新疆11选5 亚洲备用网址登入
蓝博优惠代理最占成 777优惠代理最占成 九州优惠代理最占成 U宝优惠代理最占成
新锦江优惠代理最占成 永利代理最占成 优游优惠代理最占成 优游优惠代理最占成
585sunbet.com 22sbsun.com XSB886.COM 8JAS.COM S6184.COM
288TGP.COM 729sun.com 956SUN.COM 155TGP.COM 8888XSB.COM
DC537.COM 899TGP.COM 598XTD.COM 988XTD.COM XSB358.COM
218sunbet.com 157cw.com 1112126.COM S618G.COM 729tt.com