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A 3.3 angstrom‐Resolution Structure of Hyperthermophilic Respiratory Complex III Reveals the Mechanism of its Thermal Stability, Angewandte Chemie, 28 Nov 2019
2019-11-28 | 【     】【打印】【关闭

Angewandte Chemie28 November, 2019,DOI:https://doi.org/10.1002/anie.201911554

A 3.3 angstrom - Resolution Structure of Hyperthermophilic Respiratory Complex III Reveals the Mechanism of its Thermal Stability

Guoliang Zhu, Hui Zeng, Shuangbo Zhang, Jana Juli, Xiaoyun Pang, Jan Hoffmann, Yan Zhang, Nina Morgner, Yun Zhu, Guohong Peng, Hartmut Michel, Fei Sun

Abstract

Respiratory chain complexes convert energy by coupling electron flow to transmembrane proton translocation. Owing to a lack of atomic structures of cytochrome bc1 complex (Complex III) from thermophilic bacteria, little is known about the adaptations of this macromolecular machine to hyperthermophilic environments. In this study, we purified the cytochrome bc1 complex of Aquifex aeolicus, one of the most extreme thermophilic bacteria known, and determined its structure with and without an inhibitor at 3.3 ? resolution. Several residues unique for thermophilic bacteria were detected that provide additional stabilization for the structure. An extra transmembrane helix at the N‐terminus of cyt.c1 was found to greatly enhance the interaction between cyt.b and cyt.c1, and to bind a phospholipid molecule to stabilize the complex in the membrane. These results provide the structural basis for the hyperstability of the cytochrome bc1 complex in an extreme thermal environment.

文章链接:https://onlinelibrary.wiley.com/doi/full/10.1002/anie.201911554

相关报道:http://yhyhdlzzc565.117pt.com/kyjz/zxdt/201911/t20191129_5444970.html

 

 

 

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